CaL inhibition prevents arrhythmogenic Ca 2 1 waves caused by abnormal Ca 2 1 sensitivity of RyR or SR Ca 2 1 accumulation
نویسندگان
چکیده
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ICaL inhibition prevents arrhythmogenic Ca 21 waves caused by abnormal Ca sensitivity of RyR or SR Ca accumulation
منابع مشابه
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure.
In heart failure (HF), arrhythmogenic Ca(2+) release and chronic Ca(2+) depletion of the sarcoplasmic reticulum (SR) arise due to altered function of the ryanodine receptor (RyR) SR Ca(2+)-release channel. Dantrolene, a therapeutic agent used to treat malignant hyperthermia associated with mutations of the skeletal muscle type 1 RyR (RyR1), has recently been suggested to have effects on the car...
متن کاملDantrolene prevents arrhythmogenic Ca release in heart failure
Maxwell JT, Domeier TL, Blatter LA. Dantrolene prevents arrhythmogenic Ca release in heart failure. Am J Physiol Heart Circ Physiol 302: H953–H963, 2012. First published December 16, 2011; doi:10.1152/ajpheart.00936.2011.—In heart failure (HF), arrhythmogenic Ca release and chronic Ca depletion of the sarcoplasmic reticulum (SR) arise due to altered function of the ryanodine receptor (RyR) SR C...
متن کاملBiphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak
KEY POINTS Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca transient and slows its rate of decay. In the presence of β-adrenergic stimulation, RyR-mediated Ca leak produces a biphasic decay of the Ca transient with a fast early phase and a slow late phase. Two forms of Ca leak have been studied, Ca-sensitising (induced by caffeine) an...
متن کاملPredicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes.
Of the many ongoing controversies regarding the workings of the sarcoplasmic reticulum (SR) in cardiac myocytes, two unresolved and interconnected topics are 1), mechanisms of calcium (Ca(2+)) wave propagation, and 2), speed of Ca(2+) diffusion within the SR. Ca(2+) waves are initiated when a spontaneous local SR Ca(2+) release event triggers additional release from neighboring clusters of SR r...
متن کاملAltered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition.
Changes in the behavior of the sarcoplasmic reticulum (SR) in rat ventricular myocytes were investigated under conditions of metabolic inhibition using laser-scanning confocal microscopy to measure intracellular Ca(2+) and the perforated patch-clamp technique to measure SR Ca(2+) content. Metabolic inhibition had several effects on SR function, including reduced frequency of spontaneous release...
متن کامل